VIDEO: Preventing Transmission of Mitochondrial DNA Mutations via Mitochondrial Replacement Therapy

Michio Hirano, MD
Professor of Neurology
Columbia University Medical Center

Dieter Egli, PhD
Robertson Investigator, New York Stem Cell Foundation
Assistant Professor of Pediatrics
Columbia University Medical Center

Mark Sauer, MD
Professor of Obstetrics & Gynecology,
Chief, Division of Reproductive Endocrinology
Columbia University Medical Center

Mitochondrial DNA (mtDNA) mutations are rare causes of maternally inherited genetic diseases that typically manifest as encephalomyopathies (brain and muscle disorders). Through manipulations of oocytes, it is possible to replace mutant mitochondria with normal donor mitochondria prior to in vitro fertilization. This mitochondrial replacement therapy (MRT) has been approved by the UK Parliament and is being considered by the FDA. Drs. Michio Hirano, Dieter Egli, and Mark Sauer will discuss their perspectives of MRT.

4:00-5:00pm
Rm 405A and B, Educational Center, Irving Institute for Clinical and Translational Research
10th Floor, Presbyterian Hospital (PH) Building
622 W. 168th Street