By Angela R. Bradbury et al.

Genetics in Medicine 

Multiplex genetic testing, including both moderate- and high-penetrance genes for cancer susceptibility, is associated with greater uncertainty than traditional testing, presenting challenges to informed consent and genetic counseling. The authors sought to develop a new model for informed consent and genetic counseling for four ongoing studies. They argue that a tiered-binned model for informed consent and genetic counseling has the potential to address the challenges of multiplex testing for cancer susceptibility and to support informed decision making and adaptive responses to testing.

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