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Mice Become Smarter With Addition of Single Human Gene

By Carl Engelking
Discover Magazine
September 16, 2014

In an experiment that could explain the origin of the maniacal mouse in “Pinky and the Brain,” researchers spliced a human brain gene into lab mice, and it made them smarter.

These mice aren’t taking over the world any time soon, but they are certainly adept at getting through mazes. Mice genetically modified to carry a human gene associated with speech and language, called Foxp2, learned how to find a reward in a maze significantly faster than normal mice. While this is good news for the modified mice, the findings also reveal clues about how this particular gene contributes to humans’ unique intellectual abilities.

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