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Polygenic Prediction in Psychiatry: A ONLINE Public Conference

March 10, 2020 - 8:30 am

An ONLINE Public Conference convened by The Center for Research on Ethical, Legal & Social Implications of  Psychiatric, Neurologic & Behavioral Genetics and The Hastings Center

The conference is free and open to researchers, scholars, and interested members of the Columbia University community, local colleges and universities, journalists, and the general public. Registration is required (email ry2134@cumc.columbia.edu).

Calculation of polygenic risk scores (PRSs) may soon make it possible to identify people at increased risk for a number of complex psychiatric traits, including schizophrenia and depression. The highly probabilistic and uncertain nature of PRSs, however, demands a careful assessment of their safe and responsible use in clinical settings. This interdisciplinary conference brings together leading scholars in psychiatry, genetics, philosophy and related areas to address the variety of ethical, legal, and social challenges to the prospective use of PRSs in psychiatry. 

Tuesday, March 10, 2020  • 9:00 AM –3:00 PM
This is an online ZOOM conference, for information on how to connect, please email ry2134@cumc.columbia.edu.

TO REGISTER: email ry2134@cumc.columbia.edu by March 9, 2020


9:00-9:15 – Welcome and introduction to the conference: Paul Appelbaum, Lucas Matthews

Session 1: PRS Construction and Application in Psychiatry

9:15-10:15 – “Challenges to the Portability of Polygenic Scores” •  Speaker: Molly Pzreworski

10:15-10:25 –  Break 

10:25-11:25 – “Considerations for the Clinical Implementation of PRS in Psychiatry”  •  Speaker: Jordan Smoller

Session 2: Uncertainty and Risk in PRS & Psychiatry

11:25-12:10  – “Uncertainties in Risk Estimates and their Clinical Use” •  Speaker: Paul Han

12:10-1:00 –  Lunch 

1:00-1:45  –  “Responding Ethically to Uncertainty When Using PRS in Psychiatry” •  Speaker: Ainsley Newson

1:45-2:30 –“Balancing Prevention and Respect: The Ethical Stakes of a Psychiatric Genomics Lens to Intellectual Disability” •  Speaker: Camillia Kong

2:30-3:00 – Panel and Audience Q&A

Panel: Molly Pzreworski, Jordan Smoller, Paul Han, Ainsley Newson, Camilia Kong • Moderator: Paul Appelbaum