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Predictive testing and clinical trials in Huntington’s disease: An ethical analysis

Sampaio C, Levey J, Klitzman R. Predictive testing and clinical trials in Huntington's disease: An ethical analysis. Movement disorders: official journal of the Movement Disorder Society. 2018 February;33(2):243-247. PubMed PMID: 29205501; PubMed Central PMCID: PMC5854324.
Dilemmas arise concerning how to design studies aimed at preventing or slowing Huntington's disease (HD) in mutation-positive presymptomatic individuals. HD is an autosomal-dominant neurodegenerative ... Read more »

Blue Genes? Understanding and Mitigating Negative Consequences of Personalized Information about Genetic Risk for Depression

Lebowitz MS, Ahn WK. Blue Genes? Understanding and Mitigating Negative Consequences of Personalized Information about Genetic Risk for Depression. Journal of genetic counseling. 2018 February;27(1):204-216. PubMed PMID: 28785835; PubMed Central PMCID: PMC5796841.
Personalized genetic testing for vulnerability to mental disorders is expected to become increasingly common. It is therefore important to understand whether learning about one's ... Read more »

Mood disorders in familial epilepsy: A test of shared etiology

Insel BJ, Ottman R, Heiman GA. Mood disorders in familial epilepsy: A test of shared etiology. Epilepsia. 2018 February;59(2):431-439. PubMed PMID: 29318616; PubMed Central PMCID: PMC5803440.
Objective Mood disorders are the most common comorbid conditions in epilepsy, but the cause remains unclear. One possible explanation is a shared genetic susceptibility to ... Read more »

Beneficial and Detrimental Effects of Genetic Explanations for Addiction

2017Free on Pubmed
Lebowitz MS, Appelbaum PS. Beneficial and detrimental effects of genetic explanations for addiction. The International journal of social psychiatry. 2017 December;63(8):717- 723. PubMed PMID: 29058960; PubMed Central PMCID: PMC5693609.
Background Addictions are highly stigmatized and increasingly construed as biomedical diseases caused by genes, partly to reduce stigma by deflecting blame. However, genetic explanations may ... Read more »

Everything in Moderation, Even Hype: Learning from Vaccine Controversies to Strike a Balance with CRISPR

2017Free on Pubmed
Benston S. Everything in moderation, even hype: learning from vaccine controversies to strike a balance with CRISPR. Journal of medical ethics. 2017 December;43(12):819- 823. PubMed PMID: 28473627; PubMed Central PMCID: PMC5671368
The ease and applicability of CRISPR/Cas9—a new and precise gene-editing and reproductive technology—have garnered hype and heightened concern about its potential “unprecedented and horrific ... Read more »

Testing positive for a genetic predisposition to depression magnifies retrospective memory for depressive symptoms

2017Free on Pubmed
magnifies retrospective memory for depressive symptoms. Journal of consulting and clinical psychology. 2017 November;85(11):1052-1063. PubMed PMID: 29083221; PubMed Central PMCID: PMC5679424.
Objective: Depression, like other mental disorders and health conditions generally, is increasingly construed as genetically based. This research sought to determine whether merely telling ... Read more »

Behavioral Genetics in Criminal Court

2017Free on Pubmed
Scurich N, Appelbaum PS. Behavioral Genetics in Criminal Court. Nature human behaviour. 2017 September 18;1:772-774. PubMed PMID: 29250604; PubMed Central PMCID: PMC5730091.
Introduction of genetic evidence of a predisposition to violent or impulsive behaviour is on the rise in criminal trials. However, a panoply of data ... Read more »

Supporting Women’s Autonomy in Prenatal Testing

2017Free on Pubmed
Johnston J, Farrell RM, Parens E. Supporting Women's Autonomy in Prenatal Testing. The New England journal of medicine. 2017 August 10;377(6):505-507. PubMed PMID: 28792882; PubMed Central PMCID: PMC5688876.
Current prenatal screening practices and the complexity of genomic science create a risk that early, noninvasive fetal genetic sequencing will be integrated into care ... Read more »

Self-reported race and ethnicity of US biobank participants compared to the US Census

2017Free on Pubmed
Cohn, E.G., Hamilton, N., Larson, E.L. et al. J Community Genet (2017) 8: 229. https://doi.org/10.1007/s12687-017-0308-6
Precision medicine envisions a future of effective diagnosis, treatment, and prevention grounded in precise understandings of the genetic and environmental determinants of disease. Given ... Read more »

Anticipating the Ethical Challenges of Psychiatric Genetic Testing

2017Free on Pubmed
Appelbaum, P.S. & Benston, S. Curr Psychiatry Rep (2017) 19: 39. https://doi.org/10.1007/s11920-017-0790-x
Purpose of Review Genetic testing for mental illness is likely to become increasingly prevalent as the science behind it is refined. This article identifies anticipated ... Read more »
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