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PNB Genetics News & Research

Genetics in child and adolescent psychiatry: methodological advances and conceptual issues

By: Sarah Hohmann, Nicoletta Adamo, Benjamin B. Lahey, Stephen V. Faraone, & Tobias Banaschewski European Child & Adolescent Psychiatry April 2015 Abstract Discovering the genetic basis of early-onset ... Read more »

Excess of runs of homozygosity is associated with severe cognitive impairment in intellectual disability

By: Ilaria Gandin et al. Genetics in Medicine 2015 Abstract Purpose: The harmful effects of inbreeding are well known by geneticists, and several studies have already reported cases ... Read more »

Return of individual genetic results in a high-risk sample: enthusiasm and positive behavioral change

Sarah M. Hartz et al. Genetics in Medicine 2015 Abstract Purpose: The goal of this study was to examine participant responses to disclosure of genetic results in a ... Read more »

Brain-specific Foxp1 deletion impairs neuronal development and causes autistic-like behaviour

By C. Bacon et al. Abstract Neurodevelopmental disorders are multi-faceted and can lead to intellectual disability, autism spectrum disorder and language impairment. Mutations in the ... Read more »

Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder

By: S Bavamian et al. Molecular Psychiatry 2015 Abstract Bipolar disorder (BD) is a heritable neuropsychiatric disorder with largely unknown pathogenesis. Given their prominent role in brain ... Read more »

Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder

By: Z Zhao et al. Molecular Psychiatry 2015 Abstract Schizophrenia (SCZ) and bipolar disorder (BPD) are severe mental disorders with high heritability. Clinicians have long noticed ... Read more »

Evaluating historical candidate genes for schizophrenia

By: M S Farrell, T Werge, P Sklar, M J Owen, R A Ophoff, M C O'Donovan, A Corvin, S Cichon, and P F ... Read more »

Altered mTORC1 signaling in multipotent stem cells from nearly 25% of patients with nonsyndromic autism spectrum disorders

By: A M Suzuki, K Griesi-Oliveira, C de Oliveira Freitas Machado, E Vadasz, E C Zachi, M R Passos-Bueno and A L Sertie Molecular Psychiatry 2015 Recent ... Read more »

Why Whole-Genome Testing Hurts More Than it Helps

By H. Gilbert Welch & Wylie Burke Los Angeles Times April 27, 2015 "President Obama proposes to plunk down $215 million on "precision medicine," and the National ... Read more »

Optogenetics and the Circuit Dynamics of Psychiatric Disease

By Karl Deisseroth, Amit Etkin, Robert C. Malenka JAMA May 14th, 2015 Abstract Optogenetics is a method for delivering millisecond-precision control (for activation or inhibition) to targeted cells ... Read more »
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