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Center Research Publications

Impact of Behavioral Genetic Evidence on the Adjudication of Criminal Behavior

2014
Paul Appelbaum and Nicholas Scurich. "Impact of Behavioral Genetic Evidence on the Adjudication of Criminal Behavior". J Am Acad Psychiatry Law (2014) 42:91-100.
Recent advances in behavioral genetics suggest a modest relationship among certain gene variants, early childhood experiences, and criminal behavior. Although scientific research examining this ... Read more »

The Double Helix Takes the Witness Stand: Behavioral and Neuropsychiatric Genetics in Court

2014
Paul S. Appelbaum. The Double Helix Takes the Witness Stand: Behavioral and Neuropsychiatric Genetics in Court. Neuron (2014) 82;5:946-949.
Data on neuropsychiatric and behavioral genetics have attracted legal interest, as attorneys explore their use in criminal and civil cases. These developments may assist ... Read more »

Return of secondary genomic findings vs patient autonomy: implications for medical care.

2013
Klitzman R, Appelbaum PS, Chung W. JAMA. 2013 Jul 24;310(4):369-70. doi: 10.1001/jama.2013.41709.
In April 2013, the American College of Medical Genetics (ACMG) recommended that clinical laboratories conducting whole genome sequencing (WGS) and whole exome sequencing (WES) ... Read more »

Informed consent for return of incidental findings in genomic research.

2013
Appelbaum PS, Waldman CR, Fyer A, Klitzman R, Parens E, Martinez J, Price WN 2nd, Chung WK. Genet Med. 2013 Oct 24. doi: 10.1038/gim.2013.145. [Epub ahead of print]
Purpose: Researchers face the dilemma of how to obtain consent for return of incidental findings from genomic research. We surveyed and interviewed investigators and study ... Read more »

Researchers’ views on return of incidental genomic research results: qualitative and quantitative findings.

2013
Klitzman R, Appelbaum PS, Fyer A, Martinez J, Buquez B, Wynn J, Waldman CR, Phelan J, Parens E, Chung WK. Genet Med. 2013 Nov;15(11):888-95. doi: 10.1038/gim.2013.87. Epub 2013 Jun 27.
PURPOSE: Comprehensive genomic analysis including exome and genome sequencing is increasingly being utilized in research studies, leading to the generation of incidental genetic findings. It ... Read more »

Processes and factors involved in decisions regarding return of incidental genomic findings in research.

2013
Klitzman R, Buquez B, Appelbaum PS, Fyer A, Chung WK.Genet Med. 2013 Sep 26. doi: 10.1038/gim.2013.140. [Epub ahead of print]
Purpose: Studies have begun exploring whether researchers should return incidental findings in genomic studies, and if so, which findings should be returned; however, how researchers ... Read more »

Ethics and neuropsychiatric genetics: a review of major issues

2012
Hoge SK and Appelbaum PS; International Journal of Neuropsychopharmacology 2012;15(10):1547-1557. PMC3359421.
Advances in neuropsychiatric genetics hold great hopes for improved prevention, diagnosis and treatment. However, the power of genetic testing to identify individuals at increased ... Read more »

Incidental Findings in the Era of Whole Genome Sequencing?

2013
Parens E, Appelbaum AS, Chung W; Hastings Center Report, July-August 2013; 43(4):16–19
The rise of technologies that can inexpensively sequence entire genomes means that researchers and clinicians have access to ever vaster stores of genomic data, ... Read more »