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Center Research Publications

How the Genome got a Life Span

2015
Lappé M, Landecker H. How the genome got a lifespan, in Special Issue: Epigenetics and society: potential, expectations, and criticisms. New Genetics & Society 2015;32(2):152-176. PMC4512745.
In the space of little more than a decade, ideas of the human genome have shifted significantly, with the emergence of the notion that ... Read more »

“Honey, I Sequenced the Kids:” Preventive Genomics and the Complexities of Adolescence

2015
Sabatello M, Appelbaum PS. "Honey, I sequenced the kids": preventive genomics and the complexities of decision making for adolescents. The American Journal of Bioethics Vol. 15 , Iss. 7, 2015.
How much control should individuals have over their genomic data? Although this question has been extensively discussed in debates about return of genomic incidental ... Read more »

Is There Room for Not Knowing “Everything”?

2015
Johnston J. Is there room for not knowing "everything"? Hastings Center Report 2015;45(1): inside front cover.
This fall, a recurrent theme at the meetings and conferences I attended was the benefit of learning as much as possible about one's genome ... Read more »

Effects of biological explanations for mental disorders on clinicians’ empathy

2014
Lebowitz MS, Ahn W. Effects of biological explanations for mental disorders on clinicians' empathy. Proceedings of the National Academy of Sciences. 2014;111(50):17786-17790.
Mental disorders are increasingly understood in terms of biological mechanisms. We examined how such biological explanations of patients’ symptoms would affect mental health clinicians’ ... Read more »

The Inclination to Evil and the Punishment of Crime – from the Bible to Behavioral Genetics

2014
Gold A, Appelbaum PS: The inclination to evil and the punishment of crime: from the Bible to behavioral genetics. Isr J Psychiatry Rel Sciences 2014;51(3):162-168. PMC4307608
The evolving field of behavioral genetics is gradually elucidating the complex interplay between genes and environment. Scientific data pertaining to the behavioral genetics of ... Read more »

Should life insurers have access to genetic test results?

2014
Klitzman RK, Appelbaum PS, Chung WK. Should life insurers have access to genetic test results? JAMA 2014;312(18):1855-1856. NIHMSID 628223.
Should life insurance companies have access to consumers’ genetic information? In deciding whether to sell life insurance policies and at what price, insurers routinely ... Read more »

Anticipate and Communicate: Ethical Management of Incidental and Secondary Findings in the Clinical, Research, and Direct-to-Consumer Contexts

2013
Presidential Commission for the Study of Bioethical Issues. Anticipate and Communicate: Ethical Management of Incidental and Secondary Findings in the Clinical, Research, and Direct-to-Consumer Contexts. Washington, DC, PCSBI, December 2013, pp. 26-29.
The Bioethics Commission has adopted a definitional framework, based in part on the presentation of Erik Parens at the Bioethics Commission’s Meeting 14, that ... Read more »

Impact of Behavioral Genetic Evidence on the Adjudication of Criminal Behavior

2014
Paul Appelbaum and Nicholas Scurich. "Impact of Behavioral Genetic Evidence on the Adjudication of Criminal Behavior". J Am Acad Psychiatry Law (2014) 42:91-100.
Recent advances in behavioral genetics suggest a modest relationship among certain gene variants, early childhood experiences, and criminal behavior. Although scientific research examining this ... Read more »

The Double Helix Takes the Witness Stand: Behavioral and Neuropsychiatric Genetics in Court

2014
Paul S. Appelbaum. The Double Helix Takes the Witness Stand: Behavioral and Neuropsychiatric Genetics in Court. Neuron (2014) 82;5:946-949.
Data on neuropsychiatric and behavioral genetics have attracted legal interest, as attorneys explore their use in criminal and civil cases. These developments may assist ... Read more »

Return of secondary genomic findings vs patient autonomy: implications for medical care.

2013
Klitzman R, Appelbaum PS, Chung W. JAMA. 2013 Jul 24;310(4):369-70. doi: 10.1001/jama.2013.41709.
In April 2013, the American College of Medical Genetics (ACMG) recommended that clinical laboratories conducting whole genome sequencing (WGS) and whole exome sequencing (WES) ... Read more »
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